PUBLICATIONS

Journal Publication

2025

  1. Gliner V, Levy I, Tsutsui K, Rav Acha M, Schliamser J, Schuster A and Yaniv Y.  Clinically meaningful interpretability of an AI model for ECG classification. npj Digital Medicine, 8 (1), 109, 2025.
  2. Segal G, Keidar N, Herskovitz M and Yaniv Y.  Personalized Preictal EEG Pattern Characterization: Do Timing and Localization Matter? Frontiers in Neuroscience-Translational Neuroscience, accepted, 2025.
  3. Aspis N, Weiser-Bitoun I and Yaniv Y.  Computational insights on drug effect on intrinsic stochasticity of mouse pacemaker cell activity. Biophysical Journal, accepted, 2025.

2024

  1. Elul Y, Rozenberg E, Boyarski A, Yaniv Y, Schuster A, and Bronstein A. Data driven modelling of interrelated dynamical systems. Communications Physics 7 (1), 141, 2024.
  2. Davoodi M*, Aspis N*, Drori Y*, Weiser-Bitoun I& and Yaniv Y&. LieRHRV system for remote lie detection using heart rate variability parameters. Scientific Reports, 14 (1), 30749, 2024.
    *Contributed equally &co-senior author
  3. Weiser-Bitoun I, Mazgaoker S, Eid R, Brosh I and Yaniv Y. Spatiotemporal profiling of protein kinase A activity in spontaneously beating hiPSC-derived cardiac organoids. iScience, accepted, 2024.

2023

  1. Kirschner Peretz N, Segal S, Shapira R, Shemla O, Lukyanenko Y, Brosh I, Lakatta EG, Tsutsui K and Yaniv Y. Changes in cAMP signaling are associated with age-related downregulation of spontaneously beating atrial tissue energetic indices. GeroScience, 45, 209-219, 2023.
  2. Mazgaoker S, Weiser-Bitoun I, Brosh I, Binah O and Yaniv Y.  cAMP-PKA signaling modulates the automaticity of human iPSC-derived cardiomyocytes. JGP 155(1), 2023.
  3. Arbel Ganon L, Davoodi M, Alexandrovich A and Yaniv Y. Synergy between membrane currents prevents severe bradycardia in mouse sinoatrial node tissue. International Journal of Molecular Sciences 24 (6), 5786, 2023.
  4. Segal S, Shemla O, Shapira R, Kirschner Peretz N, Lukyanenko Y, Brosh I, Lakatta EG, Tsutsui K and Yaniv Y. cAMP signaling affects age-associated deterioration of pacemaker beating interval dynamics. GeroScience 45(4):2589-2600, 2023.
  5. Keidar N, Kirschner Peretz N and Yaniv Y. Ca2+ pushes and pulls energetics to maintain ATP balance in atrial cells: computational insights. Frontiers in Physiology 14:1231259, 2023.
  6. Segal S and Yaniv Y. Ca2+-driven selectivity of the effect of the cardiotonic steroid marinobufagenin on rabbit sinoatrial node function. Cells 12(14), 1881, 2023.
  7. Arbel Ganon L, Eid R, Hamra M and Yaniv Y.   The mechano-electric feedback mediates the dual effect of stretch in mouse sinoatrial tissue. JMCC Plus 5, 10042, 2023.
  8. Gliner V, Makarov V, Avetisyan A.I, Schuster A and Yaniv Y. Using domain adaptation for classification of healthy and disease conditions from mobile-captured images of standard 12-lead electrocardiograms. Scientific Reports, 13, 14023, 2023.
  9. Segal G, Keidar N, Lotan RM, Romano Y, Herskovitz M and Yaniv Y. Utilizing risk-controlling prediction calibration to reduce false alarm rates in epileptic seizure prediction. Frontiers in Neuroscience-Translational Neuroscience, 17:1184990, 2023.
  10. Shapira R, Kedar R, Yaniv Y and Keidar N. Double-sided asymmetric method for automated fetal heart rate baseline calculation. Physical and Engineering Sciences in Medicine, 46: 1779–1790, 2023.
  11. Davoodi M, Soker A, Behar J.A and Yaniv Y. Using beat-to-beat heart signals for age-independent biometric verification. Scientific Reports, 3 (1), 16937, 2023.
  12. Mazgaoker S and Yaniv Y.  Computational insight into energy control balance by Ca2+ and cAMP-PKA signaling in pacemaker cells. Journal of Molecular and Cellular Cardiology, 185: 77-87 2023.
  13. Weiser-Bitoun I, Mori H, Nabeshima T, Tanaka N, Kudo D, Sasaki W, Narita M, Matsumoto K, Ikeda Y, Araj T, Nakano S, Sumitomo N, Senbonmatsu T, Matsumoto K, Kato R, Morrell C, Tsutsui K and Yaniv Y. Age-dependent contribution of intrinsic mechanisms to sinoatrial node function in humans. Scientific Reports, 13:18875, 2023.

2022

  1. Juhaszova M, Kobrinsky E, Zorov D.B, Nuss H.B, Yaniv Y, Fishbein K.W, de Cabo R, Montoliu L, Gabelli S.B, Aon M.A, Cortassa S and Sollott SJ. ATP synthase K+-and H+-fluxes drive ATP synthesis and enable mitochondrial K+-‘uniporter’ function: I. Characterization of ion fluxes Function 3(2):zqab065, 2022.
  2. Juhaszova M, Kobrinsky E, Zorov D.B, Nuss H.B, Yaniv Y, Fishbein K.W, de Cabo R, Montoliu L, Gabelli S.B, Aon M.A, Cortassa S and Sollott SJ. ATP synthase K+-and H+-fluxes drive ATP synthesis and enable mitochondrial K+-‘uniporter’ function: II. Ion and synthase flux regulation. Function 3(2): zqac001, 2022.
  3. Xue J-B, Val-Blasco A, Davoodi M, Gómez S, Yaniv Y, Benitah J-P, Gómez AM. Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling. Journal of General Physiology 154(9):e202112895, 2022.
  4. Xue J-B, Val-Blasco A, Davoodi M, Gómez S, Yaniv Y, Benitah J-P, Gómez AM. Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling. Journal of General Physiology 154(9):e202112895, 2022.
  5. Moen JM, Morrell CH, Ahmet I, Matt MG, Davoodi M, Petr M, Charles S, deCabo R, Yaniv Y, Lakatta EG. Emergence of heartbeat frailty in advanced age I: Perspectives from life-long EKG recordings in adult mice. GeroScience, 44, 2801–2830 2022.
  6. Kirschner Peretz N, Segal S, Weiser-Bitoun I and Yaniv Y. Distinct PKA signaling in cytosolic and mitochondrial compartments in electrically paced atrial myocytes. Cells 11 (14), 2261, 2022.

2021

  1. Shemla O, Tsutsui K, Behar J and Yaniv Y. Beating rate variability of isolated mammal sinoatrial node tissue: insight into its contribution to heart rate variability. Frontiers in Neuroscience 14:1465, 2021.
  2. Keidar N, Elul Y, Schuster A and Yaniv Y. Visualizing and quantifying irregular heart rate irregularities to identify atrial fibrillation events. Frontiers of Physiology 12: 637680, 2021.
  3. Tagirova S, Tsutsui K, Tarasov KV, Yang D, Wirth AN, Maltsev VA, Ziman BD, Yaniv Y, Lakatta EG. Self-similar synchronization of calcium and membrane potential transitions during action potential cycles predict heart rate across species. JACC: Clinical Electrophysiology 7(11), 1331-1344, 2021.
  4. Tagirova S, Tsutsui K, Tarasov KV, Yang D, Wirth AN, Maltsev VA, Ziman BD, Yaniv Y, Lakatta EG. Self-similar synchronization of calcium and membrane potential transitions during action potential cycles predict heart rate across species. JACC: Clinical Electrophysiology 7(11), 1331-1344, 2021.
  5. Elul Y, Rosenberg AA, Schuster A, Bronstein AM and Yaniv Y. Meeting the unmet needs of clinicians from AI systems showcased for cardiology with deep-learning-based ECG analysis. PNAS 118(24) 2021.
  6. Weiser-Bitoun I, Davoodi M, Rosenberg AA, Alexandrovich A and Yaniv Y. Opening the Schrödinger box: Short- and long-range mammalian heart rate variability. Frontiers of Physiology 12: 665709, 2021.

2020

  1. Kirschner Peretz N, Segal S and Yaniv Y. May the force not be with you during culture: Eliminating mechano-associated feedback during culture preserves cultured atrial and pacemaker cell functions. Frontiers in Physiology Accepted, 2020.
  2. Gliner V, Keidar N, Makarov V, Avetisyan AI, Schuster A and Yaniv Y. Automatic classification of healthy and disease conditions from images or digital standard 12-lead electrocardiograms. Scientific Reports 10 (1), 1-12, 2020.
  3. Rosenberg AA, Weiser-Bitoun I, Billman GE and Yaniv Y. Signatures of the autonomic nervous system and the heart’s pacemaker cells in canine electrocardiograms and their applications to humans. Scientific Reports Accepted, 2020.
  4. Arbel Ganon L, Behar J , Gomez AM and Yaniv Y. Distinct mechanisms mediate pacemaker dysfunction associated with catecholaminergic polymorphic ventricular tachycardia mutations: Insights from computational modeling. JMCC accepted, 2020.

2019

  1. Leichner JM, Konyukhov E, Kamoun D and Yaniv Y. Real time mitochondrial dimension measurements. Journal of Biological Methods 6(1):e111, 2019.
  2. Segal S, Kirschner Peretz N, Arbel-Ganon L, Liang J, Li L, Marbach D, Wang S and Yaniv Y. Eliminating contraction during culture maintains global and local Ca2+ dynamics in cultured rabbit pacemaker cells. Cell Calcium 78, 35-47, 2019.
  3. Moen JM, Matt MG, Ramirez C, Tarasov KV, Chakir K, Tarasova YS, Lukyanenko Y, Tsutsui K, Monfredi O, Morrell CH, Tagirova S, Yaniv Y, Huynh T, Pacak K, Ahmet I and Lakatta EG. Overexpression of a neuronal type adenylyl cyclase (type 8) in sinoatrial node markedly impacts heart rate and rhythm. Frontiers Neuroscience 18:13:615, 2019.

2018

  1. Gliner V, Behar J and Yaniv Y. Novel method to efficiently create an mHealth app: Implementation of a real-time electrocardiogram R peak detector. Journal of Medical Internet Research mHealth and uHealth 6(5):e118, 2018.  
  2. Behar JA, Rosenberg AA, Shemla O, Murphy K, Koren G, Billman G and Yaniv Y. A universal scaling relation for defining power spectral bands in mammalian heart rate variability analysis. Frontiers of Physiology 9, 1001, 2018.
  3. Kamoun D, Behar J, Leichner JM and Yaniv Y. Bioenergetic feedback between heart cell contractile machinery and mitochondrial 3D deformations. Biophysical Journal 115 (8), 1603-1613, 2018.
  4. Gliner V and Yaniv Y. An SVM approach for identifying atrial fibrillation. Physiological Measurement 39(9), 2018.
  5. Behar JA, Rosenberg AA, Weiser-Bitoun I, Shemla O, Alexandrovich A, Konyukhov E and Yaniv Y. PhysioZoo: a novel open access platform for heart rate variability analysis of mammalian electrocardiographic data. Frontiers of Physiology 9, 1390, 2018.
  6. Behar JA, Shemla O, Weiser-Bitoun I, Rosenberg AA, Yaniv Y. Adding two dimensions to heart rate variability research. Computing in Cardiology, Maastricht, Netherland, 2018.

2017

  1. Haron-Khun S, Weisbrod D, Bueno H, Yadin D, Behar J, Peretz A, Binah O, Hochhauser E, Eldar M, Yaniv Y, Arad M and Attali B. SK4 K+ channels are therapeutic targets for the treatment of cardiac arrhythmias. Experimental & Molecular Medicine. 9(4): 415-429, 2017.
  2. Davoodi M, Segal S, Kirschner Peretz N, Kamoun D and Yaniv Y. Semi-automated program for analysis of local Ca2+ spark release with application for classification of heart cell type. Cell Calcium. 64:83-90, 2017.
  3. Behar J and Yaniv Y. Age-related pacemaker deterioration is due to impaired intracellular and membrane mechanisms: insights from numerical modeling. Journal of General Physiology, 149(10):935-949 2017. Peak for JGP Research News and for the journal cover picture [PDF]
  4. Kirschner Peretz N, Segal S, Arbel-Ganon L, Ben Jehuda R, Shemer Y, Eisen B, Davoodi M, Binah O and  Yaniv Y. A method sustaining the bioelectric, biophysical, and bioenergetic function of cultured rabbit atrial cells. Frontiers in Physiology, 8:584, 2017.
  5. Behar JA, Rosenberg AA, Yaniv Y and Oster J. Rhythm and quality classification from short ECGs recorded using a mobile device. Computing in Cardiology, Accepted.
  6. Gliner V and Yaniv Y. Identification of features for machine learning analysis for automatic arrhythmogenic event classification. Computing in Cardiology, Accepted.

2016

  1. Yaniv Y. The tango between PKA and CaMKII signaling in cardiac pacemaker cells. Physiological Mini Review. 9(8):58-65,2016.
  2. Behar J, Ganesan A, Zhang J and Yaniv Y. The autonomic nervous system regulates the heart rate through cAMP-PKA dependent and independent coupled-clock pacemaker cell mechanisms. Frontiers in Physiology, 7:419, 2016.
  3. Behar J and Yaniv Y. Dynamics of PKA phosphorylation and gain-of-function in cardiac pacemaker cells: a computational model analysis. American Journal of Physiology: Heart and Circulation, 310(9):H1259-1266, 2016.
  4. Yaniv Y, Ahmet I, Tsutsui K, Behar J, Moen JM, Okamoto Y, Guiriba TR, Liu J, Bychkov R, and Lakatta EG. Deterioration of autonomic neuronal receptor signaling and mechanisms intrinsic to heart pacemaker cells contribute to age-associated alterations in heart rate variability in vivo. Cell Aging, 15(4):716-724, 2016.
  5. Sirenko S, Maltsev VA, Yaniv Y, Bychkov R, Yaeger D, Vinogradova T, Spurgeon HA, and Lakatta EG. Electrochemical Na+ and Ca2+ gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells. American Journal of Physiology: Heart and Circulation, 311(1):H251-267, 2016.

2015

  1. Yaniv Y, Ganesan A, Yang D, Lyashkov AE, Ziman B, Levchenko A, Zhang J and Edward Lakatta. Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells. Journal of Molecular and Cellular Cardiology, 86:168-178, 2015.
  2. Yaniv Y and Lakatta EG. The end effector of circadian heart rate variation: the sinoatrial node pacemaker cell. Biochemistry and Molecular Biology Reports, 48(12):677-684, 2015.
  3. Yaniv Y, Tsutsui K and Lakatta EG. Potential effects of intrinsic heart pacemaker cell mechanisms on dysrhythmic cardiac action potential firing. Frontiers in Physiology 6:47, 2015.
  4. Yaniv Y, Lakatta EG and Maltsev VA. From two competing oscillators to one coupled-clock pacemaker cell system. Frontiers in Physiology 6:28, 2015.

2014

  1. Yaniv Y, Lyashkov AE, Sirenko S, Okamoto Y, Guiriba TR, Ziman BD, Morrell CH, and Lakatta EG. Stochasticity intrinsic to coupled-clock mechanisms underlies beat-to-beat variability of spontaneous action potential firing in sinoatrial node pacemaker cells. Journal of Molecular and Cellular Cardiology, 77: 1-10, 2014.
  2. Yaniv Y and Maltsev VA. Numerical Modeling Calcium and CaMKII Effects in the SA Node. Frontiers in Pharmacology of Ion Channels and Channelopathies 5:58, 2014.